Lewis D W, Fontana C, Mehallick L K, Everett Y
Department of Pediatrics and Neurology, US Naval Hospital, Portsmouth, VA 23708.
Dev Med Child Neurol. 1994 Jun;36(6):484-6. doi: 10.1111/j.1469-8749.1994.tb11877.x.
Ten developmentally delayed children with excessive drooling were randomized in a double-blind, placebo-controlled study to assess the efficacy and safety of transdermal scopolamine. Over half of the patients had a statistically significant reduction in drooling, and one-third had cessation of drooling, while wearing the scopolamine patch. This short-term study supports earlier reports of the safety and efficacy of transdermal scopolamine for reducing excessive drooling in developmentally disabled children.
十名发育迟缓且流口水过多的儿童被随机分组，参与一项双盲、安慰剂对照研究，以评估透皮东莨菪碱的疗效和安全性。超过半数的患者在佩戴东莨菪碱贴片时，流口水情况有统计学意义上的显著减少，三分之一的患者流口水停止。这项短期研究支持了早期关于透皮东莨菪碱减少发育障碍儿童过多流口水的安全性和有效性的报告。
