Mettlin C
Roswell Park Cancer Institute, Buffalo, New York.
Clin Invest Med. 1993 Dec;16(6):440-7.
The American Cancer Society National Prostate Cancer Detection Project (ACS-NPCDP) is a multicenter, interdisciplinary demonstration project to assess the impact on early detection of transrectal ultrasound (TRUS), prostate-specific antigen (PSA), and digital rectal examination (DRE). Preliminary data are available from the first 3-5 y of planned observation. The results show declining rates of detection for each succeeding examination. Cancer detection rates are highly dependent on age. The positive predictive value of a solitary examination is low regardless of modality, but any combination of positive results has a much better predictive value. The cancers detected were predominantly clinically localized tumors, and detection of advanced stage cancer was uncommon after the initial examination. Radical prostatectomy was the most common form of treatment. These findings have implications for prostate cancer early detection guidelines and practice.
美国癌症协会国家前列腺癌检测项目（ACS-NPCDP）是一项多中心、跨学科的示范项目，旨在评估经直肠超声（TRUS）、前列腺特异性抗原（PSA）和直肠指检（DRE）对早期检测的影响。现有计划观察的前3至5年的初步数据。结果显示，后续每次检查的检测率都在下降。癌症检测率高度依赖于年龄。无论采用何种方式，单次检查的阳性预测值都很低，但任何阳性结果的组合都具有更好的预测价值。检测出的癌症主要是临床局限性肿瘤，初次检查后很少检测到晚期癌症。根治性前列腺切除术是最常见的治疗方式。这些发现对前列腺癌早期检测指南和实践具有启示意义。
