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1992年前列腺癌宣传周:主要研究结果总结

Prostate Cancer Awareness Week, 1992: a summary of key findings.

作者信息

DeAntoni E, Crawford E D, Stone N N, Blum D S, Berger E R, Eisenberger M A, Gambert S R, Staggers F

机构信息

Division of Urology, University of Colorado Health Sciences Center, Denver.

出版信息

Clin Invest Med. 1993 Dec;16(6):448-57.

PMID:7516833
Abstract

Prostate Cancer Awareness Week was begun in 1989 to investigate whether men could be recruited to participate in free prostate cancer screening. Initially designed to raise public awareness of "the ignored male disease", it has become the largest single cancer screening program in the United States. In 1992, more than 500,000 men were examined by digital rectal examination (DRE) and more than half of these also by measuring prostate-specific antigen (PSA). Although the populations examined have been generally better educated than the national average, predominantly white, and typically (> 40%) experiencing some symptom of prostate disease, adherence to annual prostate examinations remains low among successive cohorts of participants. Prostate cancers detected through this program exhibit a more favorable stage distribution than the national average. From 1989 through 1992, many cancers were detected by using the effective combination of DRE and PSA testing, which resulted in more stage A disease being diagnosed and fewer stage B, C, and D tumors. Data from 1992 suggest that increasing sophistication is possible with PSA test results, and age-specific PSA reference ranges have been developed.

摘要

前列腺癌宣传周始于1989年,旨在研究是否能够招募男性参与免费的前列腺癌筛查。该活动最初旨在提高公众对“被忽视的男性疾病”的认识,如今已成为美国规模最大的单一癌症筛查项目。1992年,超过50万名男性接受了直肠指检(DRE),其中半数以上还检测了前列腺特异性抗原(PSA)。尽管接受检查的人群总体受教育程度高于全国平均水平,主要为白人,且通常(>40%)有前列腺疾病的某些症状,但在连续几批参与者中,坚持每年进行前列腺检查的比例仍然较低。通过该项目检测出的前列腺癌在分期分布上比全国平均情况更为有利。从1989年到1992年,通过结合使用有效的DRE和PSA检测方法,发现了许多癌症,这使得更多的A期疾病被诊断出来,而B、C和D期肿瘤则较少。1992年的数据表明,随着PSA检测结果的日益精细,已制定了针对特定年龄的PSA参考范围。

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