Barton K, Lightman S
Department of Clinical Science, Institute of Ophthalmology, London, UK.
Eye (Lond). 1994;8 ( Pt 1):60-5. doi: 10.1038/eye.1994.11.
Loss of vision in posterior uveitis is often the consequence of chronic retinal oedema and immune-mediated damage to the retinal parenchyma. Research in other putative autoimmune diseases such as rheumatoid arthritis, and in animal models of autoimmune disease, has uncovered a number of mechanisms which may contribute to the development of inflammatory disease within the eye. With recent developments in specific anti-cytokine therapy an understanding of these mechanisms, most of which are cytokine-mediated, is essential in order to plan more effective therapeutic strategies. In this paper we review recent research investigating the functional characteristics of the T cells which are recruited into the retina in experimental autoimmune uveoretinitis, including activation status, antigen-specific proliferation in vitro and cytokine mRNA production in the inflamed retina.
后葡萄膜炎导致的视力丧失通常是慢性视网膜水肿和免疫介导的视网膜实质损伤的结果。对其他推定的自身免疫性疾病（如类风湿性关节炎）以及自身免疫性疾病动物模型的研究，已经发现了一些可能导致眼内炎症性疾病发展的机制。随着特异性抗细胞因子疗法的最新进展，了解这些机制（其中大多数是由细胞因子介导的）对于制定更有效的治疗策略至关重要。在本文中，我们综述了最近的研究，该研究调查了在实验性自身免疫性葡萄膜视网膜炎中募集到视网膜的T细胞的功能特征，包括激活状态、体外抗原特异性增殖以及炎症视网膜中的细胞因子mRNA产生。
