Prömpeler H J, Madjar H, Sauerbrei W, Lattermann U, du Bois A, Breckwoldt M, Pfleiderer A
Universitäts-Frauenklinik Freiburg.
Geburtshilfe Frauenheilkd. 1994 Apr;54(4):216-21. doi: 10.1055/s-2007-1023585.
In 129 patients with ovarian tumours, a preoperative examination by transvaginal colour Doppler sonography (ATL UM9 HDI) was performed. 45 were malignant and 84 benign. 46 patients were premenopausal and 83 postmenopausal. All tumour vessels were analysed by spectrum analysis. The number of tumour vessels and the lowest resistance index (RImin) and pulsatility index (PImin) of all vessels were evaluated as diagnostic criteria of the neovascularisation. Up to 19 vessels were found in 115 (89%) tumours. In benign lesions, the number of vessels was significantly lower than in malignancies (median 3 versus 9, p < 0.0001). The RImin and PImin values between benign and malignant tumours were also significantly different, independent of the menopausal status. In postmenopausal patients, the median RImin in 42 benign tumours was 0.62 (0.26-1.0) and in 41 malignancies 0.40 (0.22-0.66). The median PImin was 0.98 (0.31-5.84) in benign tumours and 0.53 (0.25-1.22) in malignant tumours. However, due to the overlapping range between benign and malignant tumours, these parameters do not allow an accurate differentiation. With a cut off value for RImin = 0.5 and PImin = 0.7, the sensitivity is 85% or 82.5% respectively. The specificity for RImin and PImin is 77%, and the diagnostic accuracy is 84% and 80% respectively. The correlation coefficient between RImin and PImin is 0.99 in benign and malignant tumours and both indices are adequate. The calculation of the RI is more easily available and should be preferred as a diagnostic parameter.
对129例卵巢肿瘤患者进行了经阴道彩色多普勒超声（ATL UM9 HDI）术前检查。其中45例为恶性肿瘤，84例为良性肿瘤。46例患者处于绝经前，83例处于绝经后。通过频谱分析对所有肿瘤血管进行分析。将肿瘤血管数量以及所有血管的最低阻力指数（RImin）和搏动指数（PImin）作为新生血管形成的诊断标准进行评估。在115例（89%）肿瘤中发现多达19条血管。良性病变中的血管数量显著低于恶性肿瘤（中位数分别为3条和9条，p < 0.0001）。无论绝经状态如何，良性和恶性肿瘤之间的RImin和PImin值也存在显著差异。在绝经后患者中，42例良性肿瘤的RImin中位数为0.62（0.26 - 1.0），41例恶性肿瘤的RImin中位数为0.40（0.22 - 0.66）。良性肿瘤的PImin中位数为0.98（0.31 - 5.84），恶性肿瘤的PImin中位数为0.53（0.25 - 1.22）。然而，由于良性和恶性肿瘤之间存在重叠范围，这些参数无法进行准确鉴别。当RImin = 0.5和PImin = 0.7作为临界值时，敏感性分别为85%或82.5%。RImin和PImin的特异性为77%，诊断准确性分别为84%和80%。良性和恶性肿瘤中RImin与PImin的相关系数为0.99，这两个指标均适用。RI的计算更容易获得，应优先作为诊断参数。
