Lyall F, Greer I A, Boswell F, Macara L M, Walker J J, Kingdom J C
Department of Obstetrics and Gynaecology, Royal Infirmary, Glasgow, UK.
Br J Obstet Gynaecol. 1994 Jun;101(6):485-7. doi: 10.1111/j.1471-0528.1994.tb13146.x.
To determine whether circulating levels of cell adhesion molecules, markers of endothelial damage and leucocyte activation, were increased in pre-eclampsia.
Serum was prepared from peripheral venous blood and stored at -70 degrees C. The cell adhesion molecules, VCAM-1, E-Selectin and ICAM-1, were measured by ELISA.
Department of Obstetrics and Gynaecology, Royal Infirmary, Glasgow.
Sixteen primigravid women with pre-eclampsia were recruited for the study. The preeclampsia group were compared with 18 healthy primigravid women with uncomplicated pregnancies.
The pre-eclamptic group had significantly higher serum levels of the cell adhesion molecule VCAM-1 (t = 3.673; P < 0.001). There were no significant differences in the adhesion molecules ICAM-1 or E-Selectin.
Endothelial damage and dysfunction are common to all the pathological features of pre-eclampsia. This study shows that concentrations of cell adhesion molecules, which indicate leucocyte-endothelial attachment and activation, are elevated in the serum of patients with pre-eclampsia. Such increases in soluble circulating cell adhesion molecules may reflect increased expression of these molecules on the endothelium and thereby explain the mechanism for leucocyte activation in pre-eclampsia.
确定子痫前期患者循环中细胞黏附分子水平（内皮损伤和白细胞活化的标志物）是否升高。
从外周静脉血制备血清并储存于-70℃。通过酶联免疫吸附测定法检测细胞黏附分子血管细胞黏附分子-1（VCAM-1）、E-选择素和细胞间黏附分子-1（ICAM-1）。
格拉斯哥皇家医院妇产科。
招募了16名单胎初产妇子痫前期患者进行研究。将子痫前期组与18名妊娠结局正常的健康单胎初产妇进行比较。
子痫前期组的细胞黏附分子VCAM-1血清水平显著更高（t = 3.673；P < 0.001）。黏附分子ICAM-1或E-选择素无显著差异。
内皮损伤和功能障碍是子痫前期所有病理特征的共同表现。本研究表明，子痫前期患者血清中指示白细胞与内皮细胞黏附及活化的细胞黏附分子浓度升高。可溶性循环细胞黏附分子的这种增加可能反映了这些分子在内皮细胞上表达增加，从而解释了子痫前期白细胞活化的机制。
