Lee G, Grehl T M, Joye J A, Kaku R F, Harter W, DeMaria A N, Mason D T
Cathet Cardiovasc Diagn. 1978;4(4):373-81. doi: 10.1002/ccd.1810040404.
Although glutaraldehyde-preserved porcine aortic Hancock heterografts have lower thromboembolism incidence than mechanical aortic valves, Hancock xenografts provide less functional aortic outflow orifices and thereby greater transvalvular gradients than mechanical prostheses. The newly developed aortic Carpentier-Edwards porcine heterografts comprise a thin-walled Elgiloy flexible metal stent covered with Teflon which provides somewhat wider internal orifices than aortic Hancock valves of the same external annulus diameter. Since aortic Carpentier-Edwards xenografts have not been clinically evaluated previously, the present study assessed cardiac function and heterograft performance (1.7 months postoperation) and clinical status (4.2 months postoperation) of 19 patients with severe aortic stenosis and/or regurgitation prior to surgery. Left ventricular end-diastolic pressures decreased (17 to 9 mm Hg), cardiac index remained normal, and clinical symptomatology diminished markedly. Mean peak transxenograft systolic pressure was only 16 mm Hg (valve area 1.73 cm2), without meaningful regurgitation. Thus aortic Carpentier-Edwards bioprostheses provide generally excellent heterograft function which appears more favorable than previous reports of Hancock xenografts.
尽管戊二醛保存的猪主动脉 Hancock 异种移植物的血栓栓塞发生率低于机械主动脉瓣，但 Hancock 异种移植物提供的功能性主动脉流出孔较少，因此与机械假体相比，跨瓣压差更大。新开发的主动脉 Carpentier-Edwards 猪异种移植物包括一个覆盖有聚四氟乙烯的薄壁 Elgiloy 柔性金属支架，与相同外部瓣环直径的主动脉 Hancock 瓣膜相比，其内部孔口稍宽。由于此前尚未对主动脉 Carpentier-Edwards 异种移植物进行临床评估，本研究评估了 19 例重度主动脉狭窄和/或反流患者术前的心脏功能和异种移植物性能（术后 1.7 个月）以及临床状况（术后 4.2 个月）。左心室舒张末期压力降低（从 17 毫米汞柱降至 9 毫米汞柱），心脏指数保持正常，临床症状明显减轻。平均跨异种移植物收缩压仅为 16 毫米汞柱（瓣口面积 1.73 平方厘米），无明显反流。因此，主动脉 Carpentier-Edwards 生物假体通常提供出色的异种移植物功能，这似乎比之前关于 Hancock 异种移植物的报道更有利。
