Harasawa Y, Imaizumi T, Ando S, Masaki H, Harada S, Momohara M, Takeshita A
Department of Biomedical Informatics, Kyushu University, Fukuoka, Japan.
Jpn Circ J. 1994 May;58(5):326-37. doi: 10.1253/jcj.58.326.
Influence of arotinolol hydrochloride and atenolol on the balance between the sympathetic and parasympathetic nervous systems was evaluated in 8 hypertensive subjects by spectral analysis of heart rate (HR) and systemic blood pressure (BP). Before and after administration of either arotinolol (n = 7) or atenolol (n = 7) for 2 weeks, BP was continuously and non-invasively monitored by a finger-cuff manometry (Finapres). A time series of instantaneous HR was constructed from the BP signal. A time series of mean BP was also constructed. Spectral analysis was performed by the use of an autoregressive algorithm on these time series (approximately 180 sec). Each spectrum was subdivided into low-(0.05-0.15 Hz, LF) and high-frequency (0.15-0.4 Hz, HF) components, and each component was divided by the sum of the two for normalization. As a measure of the balance between the sympathetic and parasympathetic nervous systems, the ratio of LF to HF (LF/HF) was evaluated. Arotinolol increased fractional HF in the HR spectrum from 0.45 +/- 0.12 to 0.73 +/- 0.08 (p < 0.01) and decreased fractional LF from 0.55 +/- 0.12 to 0.27 +/- 0.08 (p < 0.01); consequently, it decreased LF/HF from 1.4 +/- 0.5 to 0.4 +/- 0.2 (p < 0.01). Atenolol had similar effects on these parameters. Neither of these beta-adrenergic blockades produced a discernible decrease in LF/HF in the BP spectrum. In conclusion, these beta-adrenergic blockades decreased LF/HF in the HR spectrum in hypertensive subjects, which suggests that they improved the balance between the sympathetic and parasympathetic nervous systems.
通过心率（HR）和体循环血压（BP）的频谱分析，在8名高血压患者中评估了盐酸阿罗洛尔和阿替洛尔对交感神经系统和副交感神经系统之间平衡的影响。在给予阿罗洛尔（n = 7）或阿替洛尔（n = 7）2周前后，使用指套式测压法（Finapres）连续、无创地监测血压。从血压信号构建瞬时心率的时间序列。还构建了平均血压的时间序列。使用自回归算法对这些时间序列（约180秒）进行频谱分析。每个频谱被细分为低频（0.05 - 0.15 Hz，LF）和高频（0.15 - 0.4 Hz，HF）成分，每个成分除以两者之和进行归一化。作为交感神经系统和副交感神经系统之间平衡的指标，评估了LF与HF的比值（LF/HF）。阿罗洛尔使HR频谱中的HF分数从0.45±0.12增加到0.73±0.08（p < 0.01），并使LF分数从0.55±0.12降低到0.27±0.08（p < 0.01）；因此，它使LF/HF从1.4±0.5降低到0.4±0.2（p < 0.01）。阿替洛尔对这些参数有类似影响。这两种β - 肾上腺素能阻滞剂均未使BP频谱中的LF/HF出现明显下降。总之，这些β - 肾上腺素能阻滞剂降低了高血压患者HR频谱中的LF/HF，这表明它们改善了交感神经系统和副交感神经系统之间的平衡。
