托屈嗪对某些直接和间接作用诱变剂致突变性的影响。

Todralazine influence upon the mutagenicity of some direct- and indirect-acting mutagens.

作者信息

Gasiorowski K, Szyba K, Urban J

机构信息

Medical Academy, Department of Basic Medical Sciences, Wroclaw, Poland.

出版信息

Mutat Res. 1994 Jul;324(3):133-7. doi: 10.1016/0165-7992(94)90057-4.

DOI:10.1016/0165-7992(94)90057-4

PMID:7517512

Abstract

Todralazine decreased the mutagenic activity of tested direct- and indirect-acting mutagens. Despite the marked differences between efficient todralazine doses (ED50) it was observed that, in the case of tested indirect mutagens as well as in some of the direct mutagens, the decrease of mutagenicity by todralazine was very strong, exceeding 80% in some cases.

摘要

托屈嗪降低了所测试的直接和间接作用诱变剂的诱变活性。尽管有效托屈嗪剂量（ED50）之间存在显著差异，但观察到，对于所测试的间接诱变剂以及某些直接诱变剂，托屈嗪对诱变活性的降低非常显著，在某些情况下超过了80%。