Vergnes J S, Pritts I M
Bushy Run Research Center/Union Carbide Corporation, Export, PA 15632.
Mutat Res. 1994 Jul;324(3):87-91. doi: 10.1016/0165-7992(94)90051-5.
Male Fischer 344 rats and male B6C3F1 mice (10/species/group) were exposed to ethylene 6 h/day, 5 days/week, for 4 weeks. The ethylene target concentrations were 0, 40, 1000, and 3000 ppm. An ethylene oxide (EO) control group for each species was exposed under the same conditions at a target concentration of 200 ppm. Bone marrow was collected approximately 24 h after the final exposure. Polychromatic erythrocyte (PCE) to normochromatic erythrocyte (NCE) ratios were determined and 2000 PCE/animal were scored for the presence of micronuclei. Ethylene did not produce statistically significant, exposure-related increases in the frequency of micronucleated PCE (MNPCE) in the bone marrow of either rats or mice when compared to air-exposed control animals. As expected, EO exposure resulted in significant increases in the frequencies of MNPCE in both species.
将雄性Fischer 344大鼠和雄性B6C3F1小鼠（每种10只/组）每天暴露于乙烯6小时，每周5天，共4周。乙烯的目标浓度分别为0、40、1000和3000 ppm。每种动物的环氧乙烷（EO）对照组在相同条件下以200 ppm的目标浓度进行暴露。在末次暴露后约24小时采集骨髓。测定多染性红细胞（PCE）与正染性红细胞（NCE）的比例，并对每只动物2000个PCE进行微核存在情况评分。与空气暴露的对照动物相比，乙烯并未在大鼠或小鼠骨髓中产生与暴露相关的、具有统计学意义的微核化多染性红细胞（MNPCE）频率增加。正如预期的那样，环氧乙烷暴露导致两个物种的MNPCE频率显著增加。
