Petersen M E, Price D, Williams T, Jensen N, Riff K, Sutton R, Rift K [corrected to Riff K ]
Department of Cardiology, Chelsea and Westminster Hospital, London, United Kingdom.
Pacing Clin Electrophysiol. 1994 May;17(5 Pt 1):882-91. doi: 10.1111/j.1540-8159.1994.tb01429.x.
Eleven subjects (mean age 50 years, range 33-71 years), who had previously received permanent dual chamber pacemakers for cardioinhibitory vasovagal syncope, underwent paired Westminster protocol tilt tests, one with short AV delay VDD pacing and one without pacing, to test the hypothesis that continuous ventricular pacing would prevent the cardiac initiation of vasovagal syncope. Nine (82%) of the paced tilts produced positive vasovagal outcomes compared with seven (64%) of the unpaced tilts. No important differences in the heart rate or blood pressure behavior during tilt or the time to positive vasovagal outcomes were observed between the paired tilts. There was more accelerated syncope/presyncope once symptoms had developed during the paced tilts of subjects in whom both study tilts were positive, although this did not reach statistical significance (P = 0.054). This study shows that atrial synchronous ventricular pacing does not prevent the initiation, or progression, of tilt induced vasovagal syncope in predisposed subjects.
11名曾因心脏抑制型血管迷走性晕厥接受永久性双腔起搏器治疗的受试者（平均年龄50岁，范围33 - 71岁），接受了配对的威斯敏斯特方案倾斜试验，一次采用短房室延迟VDD起搏，另一次不进行起搏，以检验持续心室起搏可预防血管迷走性晕厥心脏起始的假设。与7次（64%）非起搏倾斜试验相比，9次（82%）起搏倾斜试验产生了阳性血管迷走性结果。配对倾斜试验之间在倾斜过程中的心率或血压行为或出现阳性血管迷走性结果的时间方面未观察到重要差异。在两项研究倾斜试验均为阳性的受试者的起搏倾斜试验中，一旦症状出现，晕厥/先兆晕厥加速的情况更多，尽管这未达到统计学显著性（P = 0.054）。这项研究表明，心房同步心室起搏不能预防易感受试者中倾斜诱发的血管迷走性晕厥的起始或进展。
