Dowman R
Department of Psychology, Clarkson University, Potsdam, NY 13699-5825.
Electroencephalogr Clin Neurophysiol. 1994 Jul;92(4):303-15. doi: 10.1016/0168-5597(94)90098-1.
The effects of innocuous and noxious sural nerve stimulation on the SEP scalp topography were examined in 15 human subjects. This analysis focused on the 6 stable periods (i.e., consecutive time points where the topography did not change) that were identified in the companion paper (Dowman 1994). Stable period 1 (SP1: 58-90 msec post stimulus), SP4 (178-222 msec) and SP5 (223-277 msec) showed amplitude-stimulus intensity relationships that are similar to those of neurons involved in the sensory-discriminative aspects of innocuous somatosensation. The SP1 topographic pattern showed little or no change across the innocuous and noxious stimulus levels, which together with the amplitude data suggests that SP1 is largely generated by neurons involved in innocuous somatosensation. The SP4 topographic pattern did not change appreciably across the innocuous and noxious stimulus levels, but its amplitude decreased with increasing noxious stimulation. These data suggest that SP4 is generated by neurons involved in innocuous somatosensation and that noxious inputs inhibit these cells. There were differences in the SP5 topographic patterns evoked at the innocuous and the noxious stimulus levels, which suggest SP5 also receives a contribution from neurons involved in noxious somatosensation. SP3 (135-157 msec) and SP6 (282-339 msec) are probably generated by neurons involved in noxious somatosensation. The topographic patterns of both were different at innocuous and noxious levels. SP3's amplitude-stimulus intensity function suggests that it is generated by neurons that respond to noxious inputs in a non-graded fashion. The amplitude and offset latency of SP6 increased with increasing noxious stimulation, which suggests that SP6 is generated by neurons that respond to noxious inputs in a graded fashion.
在15名人类受试者中，研究了无害和有害的腓肠神经刺激对体感诱发电位（SEP）头皮地形图的影响。该分析聚焦于在配套论文（Dowman，1994年）中确定的6个稳定期（即地形图未发生变化的连续时间点）。稳定期1（SP1：刺激后58 - 90毫秒）、SP4（178 - 222毫秒）和SP5（223 - 277毫秒）呈现出的振幅-刺激强度关系，与参与无害躯体感觉的感觉辨别方面的神经元的关系相似。SP1地形图模式在无害和有害刺激水平上几乎没有变化，这与振幅数据一起表明，SP1主要由参与无害躯体感觉的神经元产生。SP4地形图模式在无害和有害刺激水平上没有明显变化，但其振幅随着有害刺激的增加而降低。这些数据表明，SP4由参与无害躯体感觉的神经元产生，并且有害输入会抑制这些细胞。在无害和有害刺激水平下诱发的SP5地形图模式存在差异，这表明SP5也接收来自参与有害躯体感觉的神经元的贡献。SP3（135 - 157毫秒）和SP6（282 - 339毫秒）可能由参与有害躯体感觉的神经元产生。两者在无害和有害水平下的地形图模式均不同。SP3的振幅-刺激强度函数表明，它由以非分级方式对有害输入做出反应的神经元产生。SP6的振幅和偏移潜伏期随着有害刺激的增加而增加，这表明SP6由以分级方式对有害输入做出反应的神经元产生。
