芘、苯并[c]菲和苯并[g]芘的K区域氧化物和亚胺在鼠伤寒沙门氏菌中的诱变性。
Mutagenicity of K-region oxides and imines of chrysene, benzo[c]phenanthrene and benzo[g]chrysene in Salmonella typhimurium.
作者信息
Glatt H, Abu-Shqara E, Harvey R G, Blum J
机构信息
Department of Toxicology, Johannes Gutenberg University, Mainz, Germany.
出版信息
Mutat Res. 1994 Jul 16;308(2):135-41. doi: 10.1016/0027-5107(94)90148-1.
The K-region oxides and imines of chrysene, benzo[c]phenanthrene and benzo[g]chrysene were investigated for mutagenicity in Salmonella typhimurium TA98 and TA100, using two different exposure media. All six compounds were mutagenic under all four experimental conditions. The imines were 17-3800 times more potent than the corresponding oxides. Omission of KCl (125 mM) from the exposure medium resulted in enhanced mutagenic effects. The enhancement was stronger in strain TA98 (3.1-5.2-fold) than in strain TA100 (1.3-2.5-fold), suggesting an influence on the bacteria rather than on the chemicals.
使用两种不同的暴露介质，研究了屈、苯并[c]菲和苯并[g]屈的K区域氧化物和亚胺在鼠伤寒沙门氏菌TA98和TA100中的致突变性。在所有四种实验条件下，所有六种化合物均具有致突变性。亚胺的致突变性比相应的氧化物强17至3800倍。从暴露介质中省略氯化钾（125 mM）会增强致突变作用。在菌株TA98中增强作用更强（3.1至5.2倍），而在菌株TA100中增强作用较弱（1.3至2.5倍），这表明其对细菌而非化学物质有影响。
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