Marson L, McKenna K E
Department of Physiology, Northwestern University Medical School, Chicago, IL 60611.
Pharmacol Biochem Behav. 1994 Apr;47(4):883-8. doi: 10.1016/0091-3057(94)90292-5.
The effects of the neurotoxin 5,7 dihydroxytryptamine (5,7 DHT) on the urethrogenital reflex was examined in anesthetized male rats. Both ICV and intrathecal administration of 5,7 DHT produced a marked depletion (92%) of spinal 5-hydroxytryptamine (5-HT) and 5-hydroxyindole acetic acid (5-HT IAA) levels. ICV but not intrathecal administration of 5,7 DHT also caused a moderate reduction in 5-HT and 5-HT IAA levels in the medulla and hypothalamus (40-48%). No reduction in adrenergic levels were observed. In spinally intact, vehicle-treated rats the urethrogenital reflex could not be evoked. However, the urethrogenital reflex could be evoked in rats pretreated with either ICV or intrathecal 5,7 DHT prior to section of the spinal cord. These data support the hypothesis that 5-HT mediates the descending inhibition of male sexual reflexes.
在麻醉的雄性大鼠中检测了神经毒素5,7-二羟基色胺（5,7-DHT）对尿道生殖反射的影响。脑室内（ICV）和鞘内注射5,7-DHT均使脊髓5-羟色胺（5-HT）和5-羟吲哚乙酸（5-HT IAA）水平显著降低（92%）。脑室内而非鞘内注射5,7-DHT也导致延髓和下丘脑的5-HT和5-HT IAA水平适度降低（40-48%）。未观察到肾上腺素能水平降低。在脊髓完整、接受载体处理的大鼠中，无法诱发尿道生殖反射。然而，在脊髓横断前预先接受脑室内或鞘内5,7-DHT处理的大鼠中，可以诱发尿道生殖反射。这些数据支持5-HT介导雄性性反射下行抑制的假说。
