匹兹堡大学的肠道移植
Intestinal transplantation at the University of Pittsburgh.
作者信息
Todo S, Tzakis A, Reyes J, Abu-Elmagd K, Furukawa H, Nour B, Kadry Z, Fung J, Starzl T E
机构信息
Pittsburgh Transplantation Institute, University of Pittsburgh Medical Center, Pennsylvania.
出版信息
Transplant Proc. 1994 Jun;26(3):1409-10.
Our experience with clinical intestinal transplantation under FK 506 immunosuppression showed that 50% of the recipients were able to be independent from TPN after transplantation, but 10% require partial TPN with functioning grafts, 10% needed total TPN after graft removal, and 30% of the recipients died postoperatively, mostly from sepsis due to severe graft rejection. For further improvement in patient survival and in the quality of life for patients after intestinal transplantation, it is mandatory to establish a new strategy for treatment and prevention of graft rejection and systemic infection.
我们在FK 506免疫抑制下进行临床小肠移植的经验表明，50%的受者在移植后能够不再依赖全胃肠外营养（TPN），但10%的受者在移植器官功能良好的情况下仍需要部分TPN，10%的受者在移植器官切除后需要完全TPN，30%的受者术后死亡，主要死于严重移植排斥导致的败血症。为了进一步提高小肠移植患者的生存率和生活质量，必须建立一种治疗和预防移植排斥及全身感染的新策略。
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