Jedema H P, Moghaddam B
Department of Psychiatry, Yale University School of Medicine, West Haven, Connecticut 06516.
J Neurochem. 1994 Aug;63(2):785-8. doi: 10.1046/j.1471-4159.1994.63020785.x.
In vivo microdialysis was used to assess the hypothesis that the stress-induced increase in dopamine release in the prefrontal cortex is mediated by stress-activated glutamate neurotransmission in this region. Local perfusion of an alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)/kainate receptor antagonist, 6-cyano-7-nitroquinoxaline-2,3-dione, blocked the stress-induced increase in dopamine levels, whereas an NMDA receptor antagonist, 2-amino-5-phosphonopentanoic acid, at the dose tested, was not able to alter this response significantly. These data indicate that the effect of stress on dopamine release in the prefrontal cortex is mediated locally by activation of AMPA/kainate receptors, which modulate the release of dopamine in this region.
应激诱导的前额叶皮质多巴胺释放增加是由该区域应激激活的谷氨酸神经传递介导的。局部灌注α-氨基-3-羟基-5-甲基异恶唑-4-丙酸（AMPA）/海人藻酸受体拮抗剂6-氰基-7-硝基喹喔啉-2,3-二酮可阻断应激诱导的多巴胺水平升高，而在测试剂量下，N-甲基-D-天冬氨酸（NMDA）受体拮抗剂2-氨基-5-磷酸戊酸并不能显著改变这种反应。这些数据表明，应激对前额叶皮质多巴胺释放的影响是由AMPA/海人藻酸受体的激活在局部介导的，该受体调节该区域多巴胺的释放。
