Endo S, Inada K, Kasai T, Takakuwa T, Nakae H, Kikuchi M, Yamashita H, Yoshida M
Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.
Res Commun Chem Pathol Pharmacol. 1994 Apr;84(1):17-25.
We measured soluble CD14 (sCD14), plasma endotoxin, tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), IL-6, and interferon-gamma (IFN-gamma) in patients with multiple organ failure (MOF). The sCD14 level was significantly higher in septic patients with MOF than that in those without MOF and also higher in non-septic trauma patients with MOF than that in those without MOF. In the septic group with MOF, the sCD14 level correlated significantly with the TNF-alpha level but not the plasma endotoxin, IL-1 beta, IL-6, or IFN-gamma level. These results suggest that the sCD14 level reflects the degree of pathophysiology and that TNF-alpha is involved in stimulating sCD14 production.
我们检测了多器官功能衰竭（MOF）患者的可溶性CD14（sCD14）、血浆内毒素、肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）、IL-6和干扰素-γ（IFN-γ）。MOF脓毒症患者的sCD14水平显著高于无MOF的脓毒症患者，且MOF非脓毒症创伤患者的sCD14水平也高于无MOF的患者。在MOF脓毒症组中，sCD14水平与TNF-α水平显著相关，但与血浆内毒素、IL-1β、IL-6或IFN-γ水平无关。这些结果表明，sCD14水平反映了病理生理学程度，且TNF-α参与刺激sCD14的产生。
