重组粒细胞集落刺激因子成功逆转费尔蒂综合征中的中性粒细胞减少症。
Successful reversal of neutropenia in Felty's syndrome with recombinant granulocyte colony stimulating factor.
作者信息
Choi M F, Mant M J, Turner A R, Akabutu J J, Aaron S L
机构信息
Department of Medicine, University of Alberta, Canada.
出版信息
Br J Haematol. 1994 Mar;86(3):663-4. doi: 10.1111/j.1365-2141.1994.tb04805.x.
Abstract
We report two patients with Felty's syndrome and chronic skin ulcers treated successfully with recombinant granulocyte colony stimulating factor (GCSF). In both cases granulocytes returned to the normal range within days of starting treatment, and their cutaneous ulcers improved. In one patient granulocytes were maintained at normal levels with a regimen of GCSF 3 micrograms/kg twice weekly for 14 months.
摘要
我们报告了两名患有费尔蒂综合征和慢性皮肤溃疡的患者，他们通过重组粒细胞集落刺激因子（GCSF）治疗成功。在这两个病例中，粒细胞在开始治疗后的几天内恢复到正常范围，并且他们的皮肤溃疡有所改善。在一名患者中，通过每周两次给予3微克/千克的GCSF方案，粒细胞维持在正常水平达14个月。
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