Annexin V: the key to understanding ion selectivity and voltage regulation?
作者信息
Demange P, Voges D, Benz J, Liemann S, Göttig P, Berendes R, Burger A, Huber R
机构信息
Abteilung Strukturforschung, Max Planck Institut für Biochemie, Martinsried, Germany.
出版信息
Trends Biochem Sci. 1994 Jul;19(7):272-6. doi: 10.1016/0968-0004(94)90002-7.
PMID:7519374
Abstract
Annexin V is a Ca(2+)-dependent membrane-binding protein that forms voltage-dependent Ca2+ channels in phospholipid bilayers and is the first ion channel to be structurally and functionally characterized. Data outlined here indicate that key amino acid residues act as selectivity filters and voltage sensors, thereby regulating the permeability of the channel pore to ions.
摘要
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