Resnick M I, Oliver J, Drach G W
Invest Urol. 1978 Jan;15(4):295-8.
Brazilian squirrel monkey kidneys removed before and after administration of parathormone were studied by microdissection, polarizing microscopy, alizarin red and von Kossa's stains, and microchemical analysis. Intralumenal crystalline-matrix masses were observed in both groups but were increased in frequency after parathormone administration. Specific staining showed the presence of calcium and phosphorus, and specific chemical tests suggested the presence of uric acid or urate salts. Refractile alizarin red positive droplets were observed in the tubular cells of the pars convoluta in parathormone-treated animals. Urinary stone formation in these animals is unique in that the location and types of stones produced are similar to that seen in man. The squirrel monkey is a good experimental model to study renal stone disease and further studies of its etiology, structure, composition, and means of control should be performed.
通过显微解剖、偏光显微镜检查、茜素红和冯·科萨染色以及微量化学分析，对注射甲状旁腺激素前后摘除的巴西松鼠猴肾脏进行了研究。两组均观察到管腔内晶体基质团块，但注射甲状旁腺激素后其出现频率增加。特异性染色显示存在钙和磷，特异性化学检测提示存在尿酸或尿酸盐。在接受甲状旁腺激素治疗的动物的曲部肾小管细胞中观察到折光性茜素红阳性液滴。这些动物的尿路结石形成具有独特之处，即所产生结石的位置和类型与人类所见相似。松鼠猴是研究肾结石疾病的良好实验模型，应对其病因、结构、成分及控制方法进行进一步研究。
