Verhagen C, Mor F, Cohen I R
Weizmann Institute of Science, Department of Cell Biology, Rehovot, Israel.
J Neuroimmunol. 1994 Aug;53(1):65-71. doi: 10.1016/0165-5728(94)90065-5.
Uveitis of unknown etiology is known to occur in association with various systemic disorders. We now report that anterior uveitis (AU) can be produced by T cell immunity to myelin basic protein (BP) and accompanies experimental autoimmune encephalomyelitis (EAE). EAE with AU was induced in Lewis rats by immunization to BP in CFA or by immunization to various BP peptides including the encephalitogenic 71-90 peptide. Slit-lamp biomicroscopy of BP-immunized Lewis rats revealed AU, characterised by inflammation of the iris, in 73% of the eyes. The onset of AU in actively immunized rats varied between days 12 and 26, often appearing after spontaneous remission of the paralysis, the hallmark of EAE. The course of AU was progressive, affecting more than 50% of the surface of the iris in 16 of 29 diseased eyes. Like the paralysis, the AU was self-limiting: within 2 weeks the disease remitted. In addition, AU could be adoptively transferred to naive and irradiated rats by a T cell clone specific for BP peptide 71-90. The present observations are compatible with the idea that AU may be triggered by BP-reactive T cells. The myelinated nerves present in the iris have been shown to contain BP. However, these peripheral nerves would now appear to be the only peripheral nerves susceptible to acute EAE.
已知病因不明的葡萄膜炎可与多种全身性疾病相关。我们现在报告，前葡萄膜炎（AU）可由针对髓鞘碱性蛋白（BP）的T细胞免疫产生，并伴有实验性自身免疫性脑脊髓炎（EAE）。通过在完全弗氏佐剂（CFA）中免疫BP或通过免疫包括致脑炎的71 - 90肽在内的各种BP肽，在Lewis大鼠中诱导出伴有AU的EAE。对BP免疫的Lewis大鼠进行裂隙灯生物显微镜检查发现，73%的眼睛出现以虹膜炎症为特征的AU。主动免疫大鼠中AU的发病时间在第12天至26天之间变化，通常在EAE的标志性瘫痪自发缓解后出现。AU的病程呈进行性，29只患病眼睛中有16只的虹膜表面受累超过50%。与瘫痪一样，AU是自限性的：在2周内疾病缓解。此外，AU可通过对BP肽71 - 90特异的T细胞克隆过继转移至未免疫和经照射的大鼠。目前的观察结果与AU可能由BP反应性T细胞触发的观点相符。虹膜中存在的有髓神经已被证明含有BP。然而，现在看来这些周围神经是唯一易患急性EAE的周围神经。
