Cortese R, Felici F, Galfre G, Luzzago A, Monaci P, Nicosia A
Istituto di Ricerche di Biologia Molecolare P. Angeletti, Pomezia, Roma, Italy.
Trends Biotechnol. 1994 Jul;12(7):262-7. doi: 10.1016/0167-7799(94)90137-6.
Peptides displayed on phage, which mimic continuous and discontinuous epitopes, can be selected using purified antibodies or preparations of polyclonal serum. This review describes recent advances in this field, discusses the application of phage-display technology to the diagnosis of human diseases, and presents new ideas for the preparation of vaccines directed against specific epitopes on a pathogen.
展示在噬菌体上的模拟连续和不连续表位的肽段，可以使用纯化抗体或多克隆血清制剂来筛选。这篇综述描述了该领域的最新进展，讨论了噬菌体展示技术在人类疾病诊断中的应用，并提出了针对病原体上特定表位制备疫苗的新思路。
