Boulad F, Gillio A, Small T N, Bonilla M A, Philips P, Ruggiero M, Emanuel D, Ghavimi F, Kernan N A
Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
Bone Marrow Transplant. 1994 May;13(5):661-3.
We describe a patient who presented with graft failure following autologous BMT, with an initial response of the neutrophil count to rHuGM-CSF but eventual loss of this response. Subsequently, this patient responded to rHuG-CSF. This could be explained by the fact that rHuG-CSF stimulates both early and late myeloid progenitor cells whereas rHuGM-CSF stimulates mainly the intermediate myeloid progenitor cells. This finding suggests that rHuG-CSF should be investigated for the treatment of patients with graft failure following ABMT.
