Senderoff D M, Israeli D, Zhang W X, Urken M L, Weinberg H
Department of Surgery, Mount Sinai Medical Center, New York, NY.
Ann Plast Surg. 1994 May;32(5):490-5. doi: 10.1097/00000637-199405000-00009.
The ability of the prostacyclin analogue iloprost to improve survival of ischemic experimental skin flaps was investigated. Unilateral island skin flaps based on the superficial inferior epigastric vessels were raised in 70 rats and subjected to varying lengths of primary ischemia. The flaps were divided into the following four groups: group I, no perfusion washout; group II, postischemic washout with lactated Ringer's solution; group III, postischemic washout with urokinase; and group IV, postischemic washout with iloprost. Flap survival rates for group IV were significantly higher than all other groups (p < 0.05). The primary ischemia time at which 50% of the flaps failed was 8.9 hours for group I, 9.5 hours for group II, 13.3 hours for group III, and 15.3 hours for group IV. This is the first study to investigate the effect of iloprost on skin flap survival. Iloprost was found to be significantly more effective than urokinase in salvaging ischemic experimental skin flaps.
研究了前列环素类似物伊洛前列素改善缺血性实验性皮瓣存活的能力。在70只大鼠中掀起以腹壁浅血管为蒂的单侧岛状皮瓣，并使其经历不同时长的原发性缺血。皮瓣被分为以下四组：第一组，不进行灌注冲洗；第二组，缺血后用乳酸林格液冲洗；第三组，缺血后用尿激酶冲洗；第四组，缺血后用伊洛前列素冲洗。第四组的皮瓣存活率显著高于所有其他组（p<0.05）。皮瓣失败率达50%时的原发性缺血时间，第一组为8.9小时，第二组为9.5小时，第三组为13.3小时，第四组为15.3小时。这是第一项研究伊洛前列素对皮瓣存活影响的研究。结果发现，在挽救缺血性实验性皮瓣方面，伊洛前列素比尿激酶显著更有效。
