Dal Cin P, Sciot R, Aly M S, Delabie J, Stas M, De Wever I, Van Damme B, Van den Berghe H
Centre for Human Genetics, University of Leuven, Belgium.
Genes Chromosomes Cancer. 1994 Jun;10(2):131-5. doi: 10.1002/gcc.2870100208.
Ten desmoid tumors were examined by chromosome banding analysis and by in situ hybridization on short-term cultures and frozen sections. Trisomy 8 was detected in four out of ten tumors, of which only one had shown trisomy 8 by karyotype analysis. Since trisomy 8 has been reported in superficial fibromatoses, which are clinically distinct but histologically similar to desmoid tumors, the occurrence of trisomy 8 in both may be a further indication of a close relationship.
通过染色体显带分析以及对短期培养物和冰冻切片进行原位杂交，对10例硬纤维瘤进行了检查。在10例肿瘤中有4例检测到8号染色体三体性，其中只有1例通过核型分析显示为8号染色体三体性。由于在浅表性纤维瘤病中已报道有8号染色体三体性，浅表性纤维瘤病在临床上与硬纤维瘤不同，但组织学上相似，两者中均出现8号染色体三体性可能进一步表明它们之间存在密切关系。
