一氧化氮合酶抑制剂使豚鼠肠肌间神经丛乙酰胆碱释放增加。
Increase by NO synthase inhibitors of acetylcholine release from guinea-pig myenteric plexus.
作者信息
Kilbinger H, Wolf D
机构信息
Pharmakologisches Institut, Universität Mainz, Germany.
出版信息
Naunyn Schmiedebergs Arch Pharmacol. 1994 May;349(5):543-5. doi: 10.1007/BF00169145.
The effects of nitric oxide (NO) synthase inhibitors on the electrically evoked release of [3H]acetylcholine were studied in guinea-pig myenteric plexus preparations preincubated with [3H]choline. NG-monomethyl-L-arginine (EC50 5.3 mumol l-1) and NG-nitro-L-arginine (EC50 1.3 mumol l-1) concentration-dependently increased the evoked release of [3H]acetylcholine without affecting the basal outflow. The facilitatory effect of NG-mono-methyl-L-arginine was prevented by L-arginine but not by D-arginine. The results suggest that endogenous NO inhibits the depolarisation-evoked release of acetylcholine.
在预先用[3H]胆碱孵育的豚鼠肠肌丛制备物中，研究了一氧化氮（NO）合酶抑制剂对电诱发的[3H]乙酰胆碱释放的影响。NG-单甲基-L-精氨酸（EC50 5.3 μmol l-1）和NG-硝基-L-精氨酸（EC50 1.3 μmol l-1）浓度依赖性地增加了[3H]乙酰胆碱的诱发释放，而不影响基础流出量。L-精氨酸可阻止NG-单甲基-L-精氨酸的促进作用，而D-精氨酸则不能。结果表明，内源性NO抑制乙酰胆碱的去极化诱发释放。
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