Mazur L, Czyzewska A
Department of Animal Physiology, Jagiellonian University, Cracow, Poland.
Mutat Res. 1994 Sep 1;309(2):219-23. doi: 10.1016/0027-5107(94)90095-7.
The frequency of micronucleated polychromatic erythrocytes in the bone marrow of Swiss mice treated with WR-2721, at a dose of 200 mg/kg or 400 mg/kg body weight, 15 or 30 min prior to cyclophosphamide (CP) administration, at a dose of 200 mg/kg body weight, was determined 24 h after CP treatment. In mice injected with CP, the number of micronuclei in polychromatic erythrocytes was significantly increased in comparison with the controls, and in mice treated with WR-2721 and CP, the frequency of micronucleated polychromatic erythrocytes was distinctly decreased in comparison to those given CP alone. The protective effect of WR-2721 against cyclophosphamide-induced clastogenicity was shown. The effect was dependent on the dose of the thiol agent given, and it was more expressed when WR-2721 was applied at the higher dose, 400 mg/kg body weight. However, the protection by the aminothiol appeared not to depend on the time intervals between WR-2721 and CP administration to the mouse organism.
在以200mg/kg体重的剂量给予环磷酰胺（CP）前15或30分钟，给瑞士小鼠按200mg/kg或400mg/kg体重的剂量注射WR-2721，于CP处理24小时后测定小鼠骨髓中微核多色红细胞的频率。与对照组相比，注射CP的小鼠多色红细胞中的微核数量显著增加，而与单独给予CP的小鼠相比，用WR-2721和CP处理的小鼠微核多色红细胞的频率明显降低。结果显示了WR-2721对环磷酰胺诱导的致断裂性的保护作用。该作用取决于所给予的硫醇试剂的剂量，当以400mg/kg体重的较高剂量应用WR-2721时，其作用表现得更为明显。然而，氨基硫醇的保护作用似乎并不取决于WR-2721与向小鼠机体给予CP之间的时间间隔。
