伊洛前列素，前列环素的稳定类似物，能够提高组织对缺血的耐受性。
Iloprost, stable analogue of the prostacyclin, is able to improve the tissue resistance to ischaemia.
作者信息
Andreozzi G M, Di Pino L, Li Pira M, Butto G, Martini R, Signorelli S
机构信息
Chair of Angiology, Institute of Internal Medicine A. Francaviglia, University of Catania, Italy.
出版信息
Int Angiol. 1994 Mar;13(1):68-9.
On 10 patients, suffering from peripheral arterial disease, with critical limb ischaemia, the CO2 production during ischaemia has been evaluated at 1st and at 28th day of treatment with iloprost. The study demonstrated that the drug is able to improve the tissue resistance to ischaemia, with a significant (p < 0.05) reduction of the CO2 production. The authors underline that this study is one of the first confirmations, in vivo and on the man, of the previous experimental findings, made in isolated arterial tissue.
对10例患有外周动脉疾病且肢体严重缺血的患者，在使用伊洛前列素治疗的第1天和第28天评估了缺血期间的二氧化碳产生情况。研究表明，该药物能够提高组织对缺血的耐受性，二氧化碳产生量显著降低（p < 0.05）。作者强调，这项研究是对先前在离体动脉组织中所做实验结果在人体上进行的首次体内验证之一。
Zotero 插件