Enomoto N, Kurosaki M, Koizumi K, Asahina Y, Sakuma I, Murakami T, Yamamoto C, Marumo F, Sato C
Second Department of Internal Medicine, Tokyo Medical and Dental University.
Nihon Rinsho. 1994 Jul;52(7):1707-15.
We investigated the fluctuation of hepatitis C virus (HCV) quasispecies during interferon therapy by single strand conformation polymorphism (SSCP) analysis. In 13 of 16 interferon ineffective patients, the predominant HCV population was replaced with other quasispecies during the treatment. Especially, in 9 patients, a part of the HCV quasispecies, pre-existing before interferon therapy, became predominant after the therapy. These results indicate that sensitivity to interferon differs among HCV quasispecies and that interferon selects resistant HCV strains. Existence of such HCV quasispecies seems to be associated with interferon treatment failure.
我们通过单链构象多态性（SSCP）分析研究了干扰素治疗期间丙型肝炎病毒（HCV）准种的波动情况。在16例对干扰素治疗无效的患者中，有13例在治疗期间主要的HCV群体被其他准种所取代。特别是，在9例患者中，干扰素治疗前就已存在的部分HCV准种在治疗后变得占主导地位。这些结果表明，HCV准种对干扰素的敏感性不同，并且干扰素会选择耐药的HCV毒株。这种HCV准种的存在似乎与干扰素治疗失败有关。
