Yokosuka O, Hosoda K, Omata M
First Department of Medicine, Chiba University School of Medicine.
Nihon Rinsho. 1994 Jul;52(7):1841-6.
The effects of interferon on chronic hepatitis C long after the treatments were assessed biochemically, virologically and histologically. Among the 12 cases who showed normal alanine aminotransferase (ALT) levels and seroconversion of HCV RNA after treatment, histological improvements were observed in 8. In contrast, among the 11 cases who showed abnormal ALT levels and HCV viremia after treatment, histological improvements were observed in only 1. Histological improvement of the liver was thus, well correlated with normalization of ALT levels and seroconversion of HCV RNA. These data indicate that complete histological resolution of chronic hepatitis C is obtainable by elimination of the virus by interferon treatment.
在治疗结束很长时间后，从生化、病毒学和组织学方面评估了干扰素对慢性丙型肝炎的疗效。在治疗后丙氨酸转氨酶（ALT）水平正常且HCV RNA血清学转换的12例患者中，8例观察到组织学改善。相比之下，在治疗后ALT水平异常且存在HCV病毒血症的11例患者中，仅1例观察到组织学改善。因此，肝脏的组织学改善与ALT水平正常化及HCV RNA血清学转换密切相关。这些数据表明，通过干扰素治疗清除病毒可实现慢性丙型肝炎组织学的完全缓解。
