Buffington C W, Strum D P, Watanabe S
Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh, Pennsylvania.
J Cardiovasc Pharmacol. 1994 Jul;24(1):37-44. doi: 10.1097/00005344-199407000-00007.
Regional myocardial O2 consumption was measured in anesthetized dogs both in baseline conditions and during intracoronary infusion of lidocaine, verapamil, sodium citrate, or 2,3-butanedione-monoxime (BDM). Despite regional hypokinesis and dyskinesis during drug infusion, regional O2 consumption was reduced only 30-40% by lidocaine, verapamil, and citrate and not at all by BDM. These results cast doubt on an important assumption of the "hibernation" theory: the protective matching of regional perfusion and contraction.
在麻醉犬身上测量了基础状态下以及冠状动脉内输注利多卡因、维拉帕米、柠檬酸钠或2,3 - 丁二酮单肟（BDM）期间的局部心肌氧消耗。尽管在药物输注期间出现局部运动减退和运动障碍，但利多卡因、维拉帕米和柠檬酸钠仅使局部氧消耗降低30 - 40%，而BDM对局部氧消耗没有影响。这些结果对“冬眠”理论的一个重要假设提出了质疑：局部灌注与收缩的保护性匹配。
