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遗传性酶缺乏症中红细胞葡萄糖-6-磷酸脱氢酶(Gd)的电泳和动力学特性。葡萄糖-6-磷酸脱氢酶的一种新变体:Gd 克雷门丘格

[Electrophoretic and kinetic properties of erythrocyte glucose-6-phosphate dehydrogenase (Gd) in hereditary enzyme deficiency. A new variant of glucose-6-phosphate dehydrogenase : Gd Kremenchug].

作者信息

Tokarev Y N, Chernyak N B, Batishchev A I, Lamzina N V, Alexeyev G A

出版信息

Nouv Rev Fr Hematol (1978). 1978;20(4):557-64.

PMID:752149
Abstract

A study of the activity of human erythrocyte G-6-PD has been completed on a great number of normal controls, coming from different regions of the USSR. This study has led to the discovery of a new variant of erythrocytic Gd, which was named "Kremenchug" from the origin of the patient. This new Gd, has a very low Km for G-6-P, and has a greater affinity for 2-deoxyglucose-6-phosphate. The maximal activity versus the pH of the medium is also characteristic of this new Gd.

摘要

对来自苏联不同地区的大量正常对照者的人体红细胞G-6-PD活性进行了研究。这项研究发现了一种红细胞Gd的新变体,根据患者的籍贯将其命名为“克雷门丘格”。这种新的Gd对G-6-P的Km值非常低,对2-脱氧葡萄糖-6-磷酸的亲和力更大。相对于培养基pH值的最大活性也是这种新Gd的特征。

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