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哺乳动物肾功能的种属差异：5-羟吲哚乙酸，一种据报道在人类中为肾小管分泌标志物的物质，在大鼠中仅通过滤过处理。

Species differences in mammalian renal function: 5-HIAA, a reported marker of tubular secretion in humans, is handled exclusively by filtration in the rat.

作者信息

Burtin M, Elghozi J L, Laude D, Kleinknecht C

机构信息

INSERM U192, Hôpital des Enfants-Malades, Paris, France.

出版信息

Exp Nephrol. 1993 Jan-Feb;1(1):62-4.

PMID:7521767
Abstract

Renal clearance of endogenous 5-HIAA has been shown to be similar to that of PAH in humans. The present study compared 5-HIAA and PAH clearances in rats. It showed that the clearance of 5-HIAA in rats was identical to that of inulin and creatinine. This suggests that in this species, 5-HIAA is only filtered and not secreted by the tubules in contrast to what is observed in humans.

摘要

内源性5-羟吲哚乙酸（5-HIAA）的肾清除率在人体中已被证明与对氨基马尿酸（PAH）相似。本研究比较了大鼠体内5-HIAA和PAH的清除率。结果显示，大鼠体内5-HIAA的清除率与菊粉和肌酐的清除率相同。这表明，与在人体中观察到的情况相反，在该物种中，5-HIAA仅通过肾小球滤过，而不被肾小管分泌。

相似文献

1
Species differences in mammalian renal function: 5-HIAA, a reported marker of tubular secretion in humans, is handled exclusively by filtration in the rat.哺乳动物肾功能的种属差异：5-羟吲哚乙酸，一种据报道在人类中为肾小管分泌标志物的物质，在大鼠中仅通过滤过处理。
Exp Nephrol. 1993 Jan-Feb;1(1):62-4.
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