Cuckle H S, Holding S, Jones R
Department of Clinical Medicine, University of Leeds, U.K.
Prenat Diagn. 1994 May;14(5):387-90. doi: 10.1002/pd.1970140508.
Maternal serum inhibin levels were measured in 19 second-trimester pregnancies affected by fetal Down's syndrome and 95 unaffected control pregnancies matched for gestational age. A statistically significant elevation was found in the affected pregnancies compared with the controls (Wilcoxon rank sum test: one-tail P = 0.02). The median level in the cases was 1.3 times that in the controls, with 95 per cent confidence limits of 0.9-1.9. Although the inhibin levels were unrelated to those of alpha-fetoprotein and unconjugated oestriol in the same samples, there was a statistically significant correlation with human chorionic gonadotropin. This together with the relatively small elevation in cases suggests that inhibin would be of limited value in maternal screening for Down's syndrome.
对19例孕中期受胎儿唐氏综合征影响的孕妇以及95例孕龄匹配的未受影响的对照孕妇，测定了母体血清抑制素水平。与对照组相比，受影响的妊娠组中发现有统计学意义的升高（Wilcoxon秩和检验：单尾P = 0.02）。病例组的中位数水平是对照组的1.3倍，95%置信区间为0.9 - 1.9。尽管同一样本中抑制素水平与甲胎蛋白和非结合雌三醇水平无关，但与人类绒毛膜促性腺激素存在统计学意义的相关性。这一点以及病例组中相对较小的升高幅度表明，抑制素在唐氏综合征的母体筛查中价值有限。
