用雅培IMX分析仪和二氯甲烷萃取酶免疫分析法测定他克莫司（FK 506）全血浓度的多中心比较。

Multicenter comparison of tacrolimus (FK 506) whole blood concentrations as measured by the Abbott IMX analyzer and enzyme immunoassay with methylene chloride extraction.

作者信息

D'Ambrosio R, Girzaitis N, Jusko W J

机构信息

Department of Pharmaceutics, School of Pharmacy, State University of New York at Buffalo 14260.

出版信息

Ther Drug Monit. 1994 Jun;16(3):287-92. doi: 10.1097/00007691-199406000-00010.

DOI:10.1097/00007691-199406000-00010

PMID:7521979

Abstract

A multicenter comparison was made between the Abbott IMX and enzyme-linked immunosorbent assay (ELISA) procedures for analysis of tacrolimus (FK 506) in whole blood. Proficiency samples and 853 patient specimens obtained after various organ transplantations were assayed by 13 laboratories. Both groups of test samples yielded slightly lower (7 and 13%) values by the IMX method, but the difference is not clinically meaningful. The type of organ transplant was not a factor that contributed to assay variation. The Abbott IMX results were essentially equivalent to ELISA and considerably facilitates monitoring of FK 506 therapy.

摘要

进行了一项多中心比较，对比雅培IMX法和酶联免疫吸附测定（ELISA）法对全血中他克莫司（FK 506）的分析。13个实验室对熟练度样本以及853份各种器官移植后获得的患者标本进行了检测。两组测试样本通过IMX法测得的值略低（分别低7%和13%），但这种差异在临床上并无意义。器官移植的类型并非导致检测差异的因素。雅培IMX法的结果与ELISA法基本相当，极大地便利了FK 506治疗的监测。