Faissner A
Department of Neurobiology, University of Heidelberg, Germany.
Perspect Dev Neurobiol. 1993;1(3):155-64.
It is generally accepted that neuron-glia interactions play an important role in the regulation of neural development. For example, astrocytes are thought to guide migrating neuronal precursors and advancing growth cones to their destination. In addition, astrocytes have recently been ascribed a function in the segregation of forming neuronal assemblies and fiber tracts and are believed to hinder regeneration of lesioned adult central nervous system (CNS) structures. Therefore molecules that might specifically mediate neuron-glia interactions in the CNS attract considerable interest. The growing family of tenascin glycoproteins may play a key role in this context. Tenascin glycoproteins are transiently expressed by astrocytes in the nervous system and affect neuronal morphogenesis and behavior in definable ways. The present review discusses functional properties and examines seemingly contradictory effects of these extracellular matrix constituents.
人们普遍认为，神经元与神经胶质细胞的相互作用在神经发育的调节中起着重要作用。例如，星形胶质细胞被认为可以引导迁移的神经元前体细胞并将生长锥推进到它们的目的地。此外，星形胶质细胞最近被赋予了在形成神经元集合体和纤维束的分离中发挥作用的功能，并且被认为会阻碍成年中枢神经系统（CNS）受损结构的再生。因此，可能特异性介导中枢神经系统中神经元与神经胶质细胞相互作用的分子引起了相当大的关注。在这种情况下，不断增加的腱生蛋白糖蛋白家族可能起着关键作用。腱生蛋白糖蛋白在神经系统中由星形胶质细胞短暂表达，并以可确定的方式影响神经元形态发生和行为。本综述讨论了这些细胞外基质成分的功能特性，并研究了看似矛盾的作用。
