[麦角酸二乙胺和5-甲氧基-N,N-二甲基色胺对离体大鼠脑突触体摄取[³H] - 5-羟色胺高亲和力的作用]
[Action of LSD and 5-methoxy-N,N-dimethyltryptamine on the high affinity uptake of [3H]-serotonin by isolated rat brain synaptosomes].
作者信息
Uebelhack R, Franke L, Seidel K
出版信息
Acta Biol Med Ger. 1978;37(10):1611-4.
PMID:752213
Abstract
LSD (10(-7)M--10(-11)M) and 5-methoxy-N,N-dimethyltyptamine (10(-7)--10(-9)M) inhibited the high affinity uptake of [3H]-5HT into synaptosomes. These results suggest that the inhibition of the high affinity uptake is involved in the psychotomimetic action of LSD and 5MeODMT.
摘要
麦角酸二乙酰胺（10⁻⁷摩尔/升 - 10⁻¹¹摩尔/升）和5-甲氧基 - N，N - 二甲基色胺（10⁻⁷ - 10⁻⁹摩尔/升）抑制了[³H] - 5-羟色胺向突触体的高亲和力摄取。这些结果表明，高亲和力摄取的抑制与麦角酸二乙酰胺和5-甲氧基 - N，N - 二甲基色胺的拟精神病作用有关。
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