Vetrovec G W, Plumb V, Epstein A E, Kay G N
Medical College of Virginia Hospitals, Virginia Commonwealth University, Richmond 23219.
J Cardiovasc Pharmacol. 1993;22 Suppl A:S29-33.
The acute hemodynamic and electrophysiologic effects of intravenous amlodipine (2 x 10 mg), administered either alone or on a background of beta-blocker therapy, were studied in 25 patients with angina pectoris. Hemodynamic assessments showed that amlodipine produced significant decreases in systemic vascular resistance and systemic blood pressure, and increases in stroke volume and cardiac output in both treatment groups. Electrophysiologic evaluation revealed that neither sinus node function, nor HIS ventricular conduction, were altered with amlodipine. Therefore, acute intravenous administration of amlodipine alone or in combination with a beta-blocker does not appear to compromise left ventricular performance, sinus node function, or intracardiac conduction.
对25例心绞痛患者研究了静脉注射氨氯地平（2×10毫克）单独使用或在β受体阻滞剂治疗背景下使用时的急性血流动力学和电生理效应。血流动力学评估显示，在两个治疗组中，氨氯地平均使全身血管阻力和全身血压显著降低，使每搏量和心输出量增加。电生理评估显示，氨氯地平既未改变窦房结功能，也未改变希氏束-心室传导。因此，单独或与β受体阻滞剂联合急性静脉注射氨氯地平似乎不会损害左心室功能、窦房结功能或心内传导。
