Lubiniecki A S, Lupker J H
SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406.
Biologicals. 1994 Jun;22(2):161-9. doi: 10.1006/biol.1994.1022.
During the past 7 years, 14 versions of 7 rDNA proteins have been licensed which are derived from animal cell culture expression systems. These medically useful products have included hormones, coagulation factors, enzymes and a vaccine. Aspects of the molecular complexity, manufacture, control and utilization of these products are discussed. In contrast to previous generations of biological production technology, the technology for production of rDNA-derived proteins in animal cells appears to be safe.
