Furuichi T, Kohda K, Miyawaki A, Mikoshiba K
Department of Molecular Neurobiology, University of Tokyo, Japan.
Curr Opin Neurobiol. 1994 Jun;4(3):294-303. doi: 10.1016/0959-4388(94)90089-2.
Intracellular channels are located on the membranes of intracellular organelles and are involved in ion transfer, within the cytosolic compartments, in response to internal stimuli. Recently, various types of inositol 1,4,5-trisphosphate- and ryanodine-sensitive Ca(2+)-release channels, mitochondrial voltage-dependent anion channels, and a vesicular Cl- channel have been molecularly cloned and characterized, and their functional roles in the central nervous system are beginning to be clarified.
细胞内通道位于细胞内细胞器的膜上，在细胞溶质区室内参与离子转运，以响应内部刺激。最近，多种类型的对肌醇1,4,5-三磷酸和兰尼碱敏感的Ca(2+)释放通道、线粒体电压依赖性阴离子通道以及一种囊泡Cl-通道已被分子克隆和鉴定，它们在中枢神经系统中的功能作用也开始得到阐明。
