Edwards F A
Department of Pharmacology, University of Sydney, New South Wales, Australia.
Curr Opin Neurobiol. 1994 Jun;4(3):347-52. doi: 10.1016/0959-4388(94)90095-7.
ATP receptors continue to be found in an ever wider range of tissues in the brain and the periphery. Much of the recent research on these receptors focuses on features that would distinguish ATP-mediated excitatory synaptic transmission from that mediated through glutamate or acetylcholine receptors. These features include kinetics of the synaptic currents, voltage-independent calcium permeability of the underlying channels, interactions with adenosine, and various direct modulators of the ATP-gated ion channel.
三磷酸腺苷(ATP)受体不断在大脑和外周越来越广泛的组织中被发现。近期对这些受体的许多研究集中在能将ATP介导的兴奋性突触传递与通过谷氨酸或乙酰胆碱受体介导的传递区分开来的特征上。这些特征包括突触电流的动力学、基础通道的电压非依赖性钙通透性、与腺苷的相互作用以及ATP门控离子通道的各种直接调节剂。