Obermair A, Czerwenka K, Kurz C, Kaider A, Sevelda P
Universitäts-Frauenklinik, Abteilung Geburtshilfe und Gynäkologie, Allgemeines Krankenhaus Wien.
Chirurg. 1994 Jul;65(7):611-5.
Angiogenesis quantitation of 106 patients with primary breast cancer and 35 patients with adenofibroma of the breast was compared and examined to its prognostic relevance for five-years disease-free survival in breast cancer patients. Immunocytochemical staining for Factor VIII-related antigen was performed to outline vascular endothelium. We found a significant higher vessel density in breast cancer patients who experienced recurrence (17.4) than in those with no recurrence (9.4) or with adenofibroma (8.7) [p < 0.0001]. The probability of five-years recurrence-free survival for patients with a primary tumor of high vessel density was at 52.3% and 86.4% for tumors of low microvessel density (p < 0.0011). Microvessel density proved to be an independent prognostic factor for breast cancer recurrence in the Cox-Model (relative risk 2.047, p = 0.0002).
对106例原发性乳腺癌患者和35例乳腺纤维腺瘤患者的血管生成定量进行了比较，并研究了其与乳腺癌患者五年无病生存率的预后相关性。采用免疫细胞化学染色法对VIII因子相关抗原进行染色，以勾勒血管内皮。我们发现，复发的乳腺癌患者（17.4）的血管密度显著高于未复发患者（9.4）或乳腺纤维腺瘤患者（8.7）[p < 0.0001]。高血管密度原发性肿瘤患者的五年无复发生存概率为52.3%，低微血管密度肿瘤患者为86.4%（p < 0.0011）。在Cox模型中，微血管密度被证明是乳腺癌复发的独立预后因素（相对风险2.047，p = 0.0002）。
