脑型兰尼碱受体参与T细胞增殖。
Involvement of the brain type of ryanodine receptor in T-cell proliferation.
作者信息
Hakamata Y, Nishimura S, Nakai J, Nakashima Y, Kita T, Imoto K
机构信息
Department of Geriatric Medicine, Kyoto University Faculty of Medicine, Japan.
出版信息
FEBS Lett. 1994 Sep 26;352(2):206-10. doi: 10.1016/0014-5793(94)00955-4.
Cloning and sequence analysis of cDNA showed that the brain type of ryanodine receptor (RYR) is expressed in human Jurkat T-lymphocyte cells. Fura-2 measurements revealed that the RYR in T-cells functions as a ryanodine-sensitive, caffeine-insensitive Ca2+ release channel. Furthermore, ryanodine stimulated proliferation and altered the growth pattern of cultured human T-cells when added together with FK506.
cDNA的克隆和序列分析表明，脑型兰尼碱受体（RYR）在人Jurkat T淋巴细胞中表达。Fura-2测量结果显示，T细胞中的RYR作为一种对兰尼碱敏感、对咖啡因不敏感的Ca2+释放通道发挥作用。此外，当与FK506一起添加时，兰尼碱刺激培养的人T细胞增殖并改变其生长模式。
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