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内镜下放置支架治疗食管下段及贲门癌。

Endoscopic stent placement for cancer of the lower esophagus and gastric cardia.

作者信息

Spinelli P, Cerrai F G, Ciuffi M, Ignomirelli O, Meroni E, Pizzetti P

机构信息

Department of Diagnostic and Surgical Endoscopy, Istituto Nazionale Tumori, Milan, Italy.

出版信息

Gastrointest Endosc. 1994 Jul-Aug;40(4):455-7. doi: 10.1016/s0016-5107(94)70209-8.

Abstract

We reviewed our results of using stents for palliation of cancer of the lower third of the esophagus and gastric cardia. During a 14-year period, 76 patients with either lower third esophageal cancer (n = 43) or cancer of the gastric cardia (n = 33) received stents for palliation of malignant dysphagia. Successful endoscopic placement was initially achieved in all patients, with 71 patients available for follow-up. Of these, 40 (56%) were subsequently able to eat solid or semi-solid food, 25 (35%) could swallow only liquids, and 6 (8%) were unimproved. The combined early and late complication rate totalled 22%. Early complications included perforation (n = 3) and stent migration (n = 4); late complications consisted of dislodgment (n = 6), obstruction by tumor (n = 2), and severe esophagitis (n = 1). There were no procedure-related deaths, but survival at 1 year was estimated to be only 1.5%, with a median survival of 2.5 months after stent insertion. The endoscopic placement of prosthetic stents for cancer of the distal esophagus and gastric cardia entails a higher complication rate, less successful palliation, and shorter survival time compared to similar treatment for more proximal esophageal cancer.

摘要

我们回顾了使用支架缓解食管下三分之一段和贲门癌的结果。在14年期间,76例食管下三分之一段癌(n = 43)或贲门癌(n = 33)患者接受了支架置入以缓解恶性吞咽困难。所有患者最初均成功进行了内镜下支架置入,71例患者可供随访。其中,40例(56%)随后能够进食固体或半固体食物,25例(35%)仅能吞咽液体,6例(8%)无改善。早期和晚期并发症的总发生率为22%。早期并发症包括穿孔(n = 3)和支架移位(n = 4);晚期并发症包括支架脱落(n = 6)、肿瘤阻塞(n = 2)和严重食管炎(n = 1)。无与手术相关的死亡,但估计1年生存率仅为1.5%,支架置入后中位生存期为2.5个月。与近端食管癌的类似治疗相比,内镜下为远端食管癌和贲门癌置入人工支架的并发症发生率更高,缓解效果较差,生存时间更短。

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