Coltorti M, Caporaso N, Morisco F, Suozzo R, Romano M, D'Antonio M
Istituto di Medicina Generale e Metodologia Clinica, Medical School, II Policlinico, Naples, Italy.
Infection. 1994 May-Jun;22(3):183-6. doi: 10.1007/BF01716699.
It is still controversial whether the familial environment plays a role in the diffusion of HCV infection. The aim of this study was to evaluate the prevalence of anti-HCV positivity in the household contacts of patients with HCV-related chronic hepatitis. Nearly all the household contacts of 113 subjects with anti-HCV+ chronic hepatitis (100/113 spouses and 260/290 children) were investigated. Anti-HCV was determined by means of ELISA II and was confirmed by RIBA II. Anti-HCV positivity was found in 27% of the spouses and in 1.9% of the children. Prevalence of anti-HCV positivity in spouses correlated positively with the duration of the marital status. Seventeen/32 (53.1%) of anti-HCV-positive subjects were found to have chronic hepatitis. This study indicates that intrafamilial diffusion of HCV infection is mostly accounted for by horizontal, in particular spouse to spouse, transmission and that spouse to spouse transmission of HCV infection correlates positively with the duration of marital status.
家庭环境在丙型肝炎病毒（HCV）感染传播中是否起作用仍存在争议。本研究的目的是评估HCV相关慢性肝炎患者家庭接触者中抗-HCV阳性的患病率。对113例抗-HCV阳性慢性肝炎患者的几乎所有家庭接触者（100/113名配偶和260/290名子女）进行了调查。通过酶联免疫吸附测定法II（ELISA II）检测抗-HCV，并通过重组免疫印迹法II（RIBA II）进行确认。在27%的配偶和1.9%的子女中发现抗-HCV阳性。配偶中抗-HCV阳性的患病率与婚姻持续时间呈正相关。在32例抗-HCV阳性受试者中有17例（53.1%）被发现患有慢性肝炎。本研究表明，HCV感染的家庭内传播主要是由水平传播，特别是配偶间传播引起的，并且HCV感染的配偶间传播与婚姻持续时间呈正相关。
