Tamura M, Nagano Y
Hayashibara Biochemical Laboratories, Inc., Okayama, Japan.
Microbiol Immunol. 1994;38(5):407-11. doi: 10.1111/j.1348-0421.1994.tb01800.x.
Natural and recombinant human interferon-alpha (IFN-alpha) and -gamma (IFN-gamma) exert differentiation-inducing and cytocidal effects in vitro on cells of the human myeloblastic leukemia cell line ML-2. These activities of IFNs are modulated by polymyxin B (PMB), a cyclic polycationic peptide antibiotic effective on Gram-negative bacilli. The modulating effect of PMB varies according to the species of IFN, namely, PMB enhances the activities of either natural IFN-gamma or recombinant IFN-gamma, while it inhibits the effects of either natural IFN-alpha or recombinant IFN-alpha. The cause of this variety in PMB effect on IFNs remains to be clarified.
天然和重组人α干扰素（IFN-α）及γ干扰素（IFN-γ）在体外对人成髓细胞白血病细胞系ML-2的细胞具有诱导分化和杀细胞作用。这些干扰素的活性受到多粘菌素B（PMB）的调节，多粘菌素B是一种对革兰氏阴性杆菌有效的环状聚阳离子肽抗生素。PMB的调节作用因干扰素种类而异，即PMB增强天然IFN-γ或重组IFN-γ的活性，同时抑制天然IFN-α或重组IFN-α的作用。PMB对干扰素作用存在这种差异的原因尚待阐明。
