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An approach to the structure determination of nucleic acid analogues hybridized to RNA. NMR studies of a duplex between 2'-OMe RNA and an oligonucleotide containing a single amide backbone modification.一种用于确定与RNA杂交的核酸类似物结构的方法。2'-O-甲基RNA与含有单个酰胺主链修饰的寡核苷酸之间双链体的核磁共振研究。
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Solution structure of the nogalamycin-DNA complex.诺加霉素 - DNA 复合物的溶液结构
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Effects of the introduction of L-nucleotides into DNA. Solution structure of the heterochiral duplex d(G-C-G-(L)T-G-C-G).d(C-G-C-A-C-G-C) studied by NMR spectroscopy.L-核苷酸引入DNA的效应。通过核磁共振光谱研究的异手性双链体d(G-C-G-(L)T-G-C-G).d(C-G-C-A-C-G-C)的溶液结构。
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Solution conformation of the N-(deoxyguanosin-8-yl)-1-aminopyrene ([AP]dG) adduct opposite dC in a DNA duplex.DNA双链中与dC相对的N-（脱氧鸟苷-8-基）-1-氨基芘（[AP]dG）加合物的溶液构象。
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Solution structure of RNA duplexes containing alternating CG base pairs: NMR study of r(CGCGCG)2 and 2'-O-Me(CGCGCG)2 under low salt conditions.含交替CG碱基对的RNA双链体的溶液结构：低盐条件下r(CGCGCG)2和2'-O-Me(CGCGCG)2的核磁共振研究
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Synthesis and studies on the effect of 2-thiouridine and 4-thiouridine on sugar conformation and RNA duplex stability.2-硫代尿苷和4-硫代尿苷对糖构象及RNA双链稳定性的影响的合成与研究
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本文引用的文献

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Matrix-assisted laser desorption ionization time-of-flight mass spectrometry: a powerful tool for the mass and sequence analysis of natural and modified oligonucleotides.基质辅助激光解吸电离飞行时间质谱：用于天然和修饰寡核苷酸质量与序列分析的强大工具。
Nucleic Acids Res. 1993 Jul 11;21(14):3191-6. doi: 10.1093/nar/21.14.3191.
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Unusual conformation of a 3'-thioformacetal linkage in a DNA duplex.DNA双链中3'-硫代缩醛连接的异常构象。
J Biomol NMR. 1994 Jan;4(1):17-34. doi: 10.1007/BF00178333.
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Effective water resonance suppression in 1D- and 2D-FT-1H-NMR spectroscopy of biopolymers in aqueous solution.水溶液中生物聚合物一维和二维傅里叶变换氢核磁共振光谱法中有效的水共振抑制
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Assignment of the non-exchangeable proton resonances of d(C-G-C-G-A-A-T-T-C-G-C-G) using two-dimensional nuclear magnetic resonance methods.使用二维核磁共振方法对d（C-G-C-G-A-A-T-T-C-G-C-G）的非交换质子共振进行归属
J Mol Biol. 1983 Dec 15;171(3):319-36. doi: 10.1016/0022-2836(83)90096-7.
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Conformational analysis of a hybrid DNA-RNA double helical oligonucleotide in aqueous solution: d(CG)r(CG)d(CG) studied by 1D- and 2D-1H NMR spectroscopy.水溶液中一种DNA-RNA杂交双螺旋寡核苷酸的构象分析：通过一维和二维氢核磁共振光谱研究d(CG)r(CG)d(CG)
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An evaluation of computational strategies for use in the determination of protein structure from distance constraints obtained by nuclear magnetic resonance.用于从核磁共振获得的距离约束确定蛋白质结构的计算策略评估。
Prog Biophys Mol Biol. 1991;56(1):43-78. doi: 10.1016/0079-6107(91)90007-f.
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Errors in RNA NOESY distance measurements in chimeric and hybrid duplexes: differences in RNA and DNA proton relaxation.嵌合和杂交双链体中RNA NOESY距离测量的误差：RNA和DNA质子弛豫的差异
Biochemistry. 1992 Apr 28;31(16):3940-6. doi: 10.1021/bi00131a008.
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Probing structural factors stabilizing antisense oligonucleotide duplexes: NMR studies of a DNA.DNA duplex containing a formacetal linkage.探索稳定反义寡核苷酸双链体的结构因素：含缩醛连接的DNA·DNA双链体的核磁共振研究
Biochemistry. 1992 Jul 14;31(27):6228-36. doi: 10.1021/bi00142a009.

一种用于确定与RNA杂交的核酸类似物结构的方法。2'-O-甲基RNA与含有单个酰胺主链修饰的寡核苷酸之间双链体的核磁共振研究。

An approach to the structure determination of nucleic acid analogues hybridized to RNA. NMR studies of a duplex between 2'-OMe RNA and an oligonucleotide containing a single amide backbone modification.

作者信息

Blommers M J, Pieles U, De Mesmaeker A

机构信息

Ciba-Geigy AG, Basel, Switzerland.

出版信息

Nucleic Acids Res. 1994 Oct 11;22(20):4187-94. doi: 10.1093/nar/22.20.4187.

DOI:10.1093/nar/22.20.4187
PMID:7524037
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC331917/
Abstract

The backbone modification amide-3, in which -CH2-NH-CO-CH2- replaces -C5'H2-O5'-PO2-O3'-, is studied in the duplex d(G1-C2-G3-T4.T5-G6-C7-G8)*mr(C9-G10-C11-A12-A13-C14-G15+ ++-C16) where . indicates the backbone modification and mr indicates the 2'-OMe RNA strand. The majority of the exchangeable and non-exchangeable resonances have been assigned. The assignment procedure differs from standard methods. The methyl substituent of the 2'-OMe position of the RNA strand can be used as a tool in the interpretation. The duplex structure is a right-handed double helix. The sugar conformations of the 2'-OMe RNA strand are predominantly N-type and the 2'-OMe is positioned at the surface of the minor groove. In the complementary strand, only the sugar of residue T4 is found exclusively in N-type conformation. The incorporation of the amide modification does not effect very strongly the duplex structure. All bases are involved in Watson-Crick base pairs.

摘要

对主链修饰酰胺-3进行了研究，其中-CH2-NH-CO-CH2-取代了-C5'H2-O5'-PO2-O3'-，研究对象为双链d(G1-C2-G3-T4.T5-G6-C7-G8)*mr(C9-G10-C11-A12-A13-C14-G15+ ++-C16)，其中.表示主链修饰，mr表示2'-OMe RNA链。大多数可交换和不可交换的共振峰已被归属。归属过程与标准方法不同。RNA链2'-OMe位置的甲基取代基可作为解释中的一种工具。双链结构为右手双螺旋。2'-OMe RNA链的糖构象主要为N型，且2'-OMe位于小沟表面。在互补链中，仅残基T4的糖完全以N型构象存在。酰胺修饰的引入对双链结构的影响不是很强。所有碱基都参与了沃森-克里克碱基对。