Gabriel S E, Brigman K N, Koller B H, Boucher R C, Stutts M J
Department of Medicine, University of North Carolina, Chapel Hill 27599.
Science. 1994 Oct 7;266(5182):107-9. doi: 10.1126/science.7524148.
The effect of the number of cystic fibrosis (CF) alleles on cholera toxin (CT)-induced intestinal secretion was examined in the CF mouse model. CF mice that expressed no CF transmembrane conductance regulator (CFTR) protein did not secrete fluid in response to CT. Heterozygotes expressed 50 percent of the normal amount of CFTR protein in the intestinal epithelium and secreted 50 percent of the normal fluid and chloride ion in intestinal epithelium and secreted 50 percent of the normal fluid and chloride ion and fluid secretion suggests that CF heterozygotes might possess a selective advantage of resistance to cholera.
在囊性纤维化（CF）小鼠模型中，研究了囊性纤维化等位基因数量对霍乱毒素（CT）诱导的肠道分泌的影响。不表达CF跨膜传导调节因子（CFTR）蛋白的CF小鼠对CT不产生液体分泌反应。杂合子在肠道上皮中表达的CFTR蛋白量为正常量的50%，并分泌正常量50%的液体和氯离子，且液体分泌表明CF杂合子可能具有对霍乱抗性的选择性优势。
