Wenstrom K D, Owen J, Boots L R, DuBard M B
Department of Obstetrics and Gynecology, University of Alabama at Birmingham 35233-7333.
Am J Obstet Gynecol. 1994 Oct;171(4):1038-41. doi: 10.1016/0002-9378(94)90030-2.
Our purpose was to determine whether abnormal pregnancy outcome is associated with elevated maternal serum human chorionic gonadotropin levels.
Maternal serum alpha-fetoprotein and human chorionic gonadotropin levels were measured in stored second-trimester serum obtained before scheduled genetic amniocentesis from 126 women with poor pregnancy outcomes, excluding aneuploidy and structural abnormalities (complications group), and 126 matched women with normal outcomes (control group).
More women with complications had elevated human chorionic gonadotropin levels (> or = 2.0 multiples of the median) (14%) than did control women (3%) (p = 0.01). Both elevated human chorionic gonadotropin and maternal serum alpha-fetoprotein levels were significantly associated with preterm delivery and fetal death. Elevated maternal serum alpha-fetoprotein was significantly associated with early postamniocentesis complications and fetal growth restriction, whereas elevated human chorionic gonadotropin was associated with preeclampsia.
Elevated human chorionic gonadotropin, similar to unexplained elevated maternal serum alpha-fetoprotein, is significantly associated with abnormal pregnancy outcomes.
我们的目的是确定异常妊娠结局是否与孕妇血清人绒毛膜促性腺激素水平升高有关。
在计划进行遗传羊膜穿刺术之前，从126名妊娠结局不良的妇女（不包括非整倍体和结构异常，并发症组）和126名匹配的结局正常的妇女（对照组）的孕中期储存血清中测量母血清甲胎蛋白和人绒毛膜促性腺激素水平。
与对照组妇女（3%）相比，并发症组中有更多妇女的人绒毛膜促性腺激素水平升高（≥中位数的2.0倍）（14%）（p = 0.01）。人绒毛膜促性腺激素水平升高和母血清甲胎蛋白水平升高均与早产和胎儿死亡显著相关。母血清甲胎蛋白水平升高与羊膜穿刺术后早期并发症和胎儿生长受限显著相关，而人绒毛膜促性腺激素水平升高与子痫前期相关。
人绒毛膜促性腺激素水平升高与原因不明的母血清甲胎蛋白水平升高相似，与异常妊娠结局显著相关。
