Richardson B, Powers D, Hooper F, Yung R L, O'Rourke K
University of Michigan, Ann Arbor.
Arthritis Rheum. 1994 Sep;37(9):1363-72. doi: 10.1002/art.1780370915.
To determine if DNA methylation inhibitors make T cells autoreactive by inducing lymphocyte function-associated antigen type 1 (LFA-1) (CD11a/CD18) overexpression.
T cell clones were treated with 3 distinct DNA methylation inhibitors or were stably transfected with a CD18 cDNA in a mammalian expression vector, and the effects on LFA-1 expression and activation requirements were examined.
LFA-1 overexpression, caused by DNA methylation inhibitors or by transfection, correlates with the development of autoreactivity.
LFA-1 overexpression may contribute to T cell autoreactivity.
